Seminar: Lin Li [Clemson University]
Developing multi-scale approach to reveal the mechanism of molecular motor's motilities and functions
Jan 24, 2017 11:00 AM to Jan 24, 2017 12:00 PM at
Electrostatic interactions play important roles in many biological phenomena. Therefore, a lot of efforts have been made to model the electrostatic interactions in biological systems. However, it is extremely challenging to accurately calculate the electrostatic interactions in large biological systems such as dynein, a molecular motor important for cargo transportation and force generation in cells. Dysfunction of dynein is associated with many diseases, such as ciliopathies, lissencephaly and other neurodegeneration disorders. I will introduce a novel multi-scale simulation approach which is used to study dynein’s motion along microtubules. The electrostatic binding funnel around microtubule is observed, which drags the dynein to the binding pocket. The electrostatic forces on dynein residues form a torsion which reorients the dynein when it is in an un-native orientation. Furthermore, the electrostatic component of the binding energy of dynein and microtubule strongly affects the velocity and run length of the dynein. These results reveal the mechanisms of dynein’s motilities and functions along microtubule. Understanding such fundamental mechanisms sheds light on curing many molecular motor related diseases.
10:50 a.m. Refreshments
11:00 a.m. Seminar
Building 8 - Room 241
For further information, please call (909) 869-4014