Seminar: Akash Bhattacharya [University Texas Health Science Center, San Antonio]
The Biophysics of HIV Infection: New Strategies for Drug Discovery
Jan 18, 2018 11:00 AM to Jan 18, 2018 12:00 PM at 8-241
HIV/AIDS is a global pandemic with an enormous human and economic cost. Various steps in the life cycle of the Human Immunodeficiency Virus have been studied and targeted by anti-retroviral drugs. However, much more needs to be accomplished in terms of developing newer, more potent, less toxic and inexpensive drugs. The HIV capsid is a protein shell that protects the HIV genome and delivers it into infected cells. During the infection process, various host cell proteins are recruited and subverted by the HIV capsid.
In this talk, I shall discuss several biophysical techniques (Fluorescence Polarization, Analytical Ultracentrifugation, NMR Spectroscopy, X-Ray crystallography, Calorimetry) and demonstrate how these techniques were applied to investigate the interaction of the HIV capsid and host cell proteins. I shall further show how small molecule drug candidates can disrupt this HIV capsid – host cell protein interaction. HIV capsid recognition and stability has not been previously been targeted by commercial drugs. Therefore, this is a novel avenue for rational drug discovery with significant public health implications.
10:50 am Refreshments
11:00 am Seminar
Building 8, Room 241