Andrew D Steele

Andrew D Steele

Professor of Biological Sciences, Biological Sciences, College of Science





Pre-print of Firozeh Farahmand's MS work now available:



Feeding, activity, and circadian papers:

Tang Q, Assali DR, Güler AD, and AD Steele (2022) Dopamine systems and biological rhythms: Let's get a move on. Front Integr Neurosci. 2022 Jul 27; 16:957193.

Trzeciak J and AD Steele (2022). Studying Food Entrainment: Models, Methods, and Musings. Front. Nutr. 9:998331.

Scarpa L, Wanken B, Smidt M, Mistlberger RE, and AD Steele (2022) Mice hypomorphic for Pitx3 show robust entrainment of circadian behavioral and metabolic rhythms to scheduled feeding. Cell Reports (Matters Arising) 38(2), 109865

Assali DR, Sidikpramana M, Villa AP, Falkenstein J, and AD Steele (2021) Type 1 dopamine receptor (D1R)-independent circadian food anticipatory activity in mice PLoS ONE 16(2): e0242897

Gallardo CM, Martin CS, and AD Steele (2020) Food Anticipatory Activity on circadian time scales is not dependent on central serotonin: evidence from tryptophan hydroxylase-2 and serotonin transporter knockout mice. Frontiers in Molecular Neuroscience 13: 534238

Grippo RM, Tang Q, Zhang Q, Chadwick SR, Gao Y, Altherr ED, Sipe L, Purohit AM, Purohit NM, Sunkara MD, Cios KJ, Sidikpramana M, Spano AJ, Campbell JN, Steele AD, Hirsh J, Deppmann CD, Wu M, Scott MM, AD Güler (2020) Dopamine Signaling in the Suprachiasmatic Nucleus Enables Weight Gain Associated with Hedonic Feeding. Current Biology 30: 1-13

Assali D*, Hsu CT*, Gunapala K, Aguayo A, McBurney M, and AD Steele (2018) Food anticipatory activity on a calorie-restricted diet is independent of Sirt1  PLoS ONE 13(6): e0199586

Aguayo A*, Martin CS*, Huddy TF, Ogawa-Okada M, Adkins JL, AD Steele (2018) Sex differences in circadian food anticipatory activity are not altered by individual manipulations of sex hormones or sex chromosome copy number in mice. PLoS ONE 13(1): e0191373

Michalik M, Steele AD, and RE Mistlberger (2015) A sex difference in circadian food-anticipatory rhythms in mice: Interaction with dopamine D1 receptor knockout. Behav Neurosci 129(3):351-60

AD Steele and RE Mistlberger (2015) Activity is a slave to many masters. eLife 4:e06351

Gallardo CM*, Darvas M*, Oviatt M, Chang C, Michalik M, Huddy TF, Meyer EE, Shuster SA, Aguayo, A, Hill EM, Kiani K, Ikpeazu J, Martinez JS, Purpura M, Smit AN, Paton D, Mistlberger RE, Palmiter R, AD Steele (2014) Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice. eLife

Gallardo CG, Hsu CT, Gunapala KM, Parfyonov M, Chang CH, Mistlberger RE, and AD Steele (2014) Behavioral and Neural Correlates of Acute and Scheduled Hunger in C57BL/6 Mice. PLoS ONE 9(5): e95990

Gallardo CM, Gunapala K, King OD and AD Steele (2012) Daily scheduled high fat meals moderately entrain behavioral anticipatory activity, body temperature, and hypothalamic c-Fos activation. PLoS ONE 7(7): e41161

Luby M, Hsu CT, Shuster SA, Gallardo CM, Mistlberger R, King OD and AD Steele (2012) Food anticipatory activity behavior of mice across a wide range of circadian and non-circadian intervals. PLoS ONE 7(5): e37992

Carlisle H, Luong T, Medina-Marino A, Schenker L, Khorosheva E, Indersmitten T, Gunapala K, Steele AD, O'Dell T, Patterson PH, and MB Kennedy (2011) Deletion of densin-180 reduces mGluR5 and DISC1 in the postsynaptic density and results in abnormal behaviors associated with mental illness. The Journal of Neuroscience 31: 16194

Gunapala K, Gallardo CM, Hsu CT and AD Steele (2011) Single gene deletions of orexin, leptin, and neuropeptide Y do not appreciably alter food anticipatory activity induced by caloric restriction. PLoS ONE 6(3):e18377

Gunapala K, Chang D, Hsu CT, Manaye K, Switzer RC and AD Steele (2010) Striatal pathology underlies prion infection-mediated hyperactivity in mice. Prion 4(4): 302-15

Hsu CT, Dollar P, Chang D and AD Steele (2010) Daily timed sexual interaction induces moderate anticipatory activity in mice. PLoS ONE 5(11): e15429

Hsu CT, Patton DF, Mistlberger RE* and AD Steele* (2010) Palatable meal anticipation in mice. PLoS ONE 5(9): e12903

Jhuang H, Garrote E, Mutch J, Yu L, Khilnani V, Poggio T, Steele AD* and T Serre* (2010) Automated home-cage behavioral phenotyping of mice. Nature Communications 1:68

Drenan RM, Grady SR, Steele AD, McKinney S, Patzlaff NE, McIntosh JM, Marks MJ, Miwa J and HA Lester (2010) Cholinergic Modulation of Locomotion and Striatal Dopamine Release is Mediated by a6a4* Nicotinic Acetylcholine Receptors. The Journal of Neuroscience 30(29):9877-9889

Chen D, Steele AD, Lindquist SL, and L Guarente (2005) Increase in activity during calorie restriction requires Sirt1. Science 310(5754):1641



Neurodegenerative diseases

Miranda, D, et al. (2017) Progressive Cl− channel defects reveal disrupted skeletal muscle maturation in R6/2 Huntington's mice. J. General Physiology 149 (1): 55-74

Bremer J, Baumann F, Tiberi C, Schwarz P, Wessig C, Steele AD, Toyka KV, Nave KA, Weis J, and A Aguzzi (2010) Axonal prion protein is required for peripheral myelin maintenance. Nature Neuroscience 13(3):310-8

Steele AD, Zhou Z, Jackson WS, Zhu C, Auluck P, Moskowitz MA, Chesselet MF, and S Lindquist (2009) Context dependent neuroprotective properties of prion protein (PrP). Prion 3(4): 1-6

Jackson WS, Borkowski AW, Faas H, Steele AD, King OD, Watson N, Jasanoff A, and Susan Lindquist (2009) Spontaneous generation of prion infectivity in fatal familial insomnia knock-in mice. Neuron 63(4):438-50

Wacker J, Huang SY, Steele AD, Aron R, Lotz G, Nguyen QV, Giorgini F, Roberson E, Lindquist S, Masliah E, and P Muchowski (2009) Loss of Hsp70 Exacerbates Pathogenesis but not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease. The Journal of Neuroscience 29(28):9104-14

Aguzzi A and AD Steele (2009) Prion topology and toxicity (preview). Cell 137(6): 994-96

Chen D*, Steele AD*, Hutter G, Bruno J, Govindarajan A, Easlon E, Lin S, Aguzzi A, Lindquist S, and L Guarente (2008) The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration. Experimental Gerontology 43(12):1086-93

Steele AD, Hutter G, Jackson WS, Heppner FL, Borkowski AW, King OD, Raymond G, Aguzzi A, and S Lindquist (2008) A critical protective role for heat shock factor 1 in prion pathogenesis. Proc Natl Acad Sci USA 105(36):13626-31

Wang H, Duennwald ML, Roberts BE, Rozeboom LM, Zhang YL, Steele AD, Krishnan R, Su LJ, Griffin D, Mukhopadhyay S, Hennessy EJ, Jansat S, Weigele P, Blanchard BJ, King J, Deniz AA, Buchwald SL, Ingram VM, Lindquist S, and J Shorter (2008) Direct and Selective Elimination of Specific Prions and Amyloids by 4,5-Dianilinophthalimide and Analogs. Proc Natl Acad Sci USA 105(20):7159-64

Steele AD (2008) All is quiet on the neuronal front: NMDA receptor inhibition by prion protein. Journal of Cell Biology 181(3): 407-409

Steele AD, Hetz C, Yi CH, Jackson WS, Borkowski AW, Yuan J, Wollman RH, and S Lindquist (2007) Prion pathogenesis is independent of Caspase 12. Prion 1(4): 243-247

Steele AD, King OD, Jackson WS, Hetz CA, Borkowski AW, Thielen P, Wollmann RH, and S Lindquist (2007) Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo. The Journal of Neuroscience 27(47):13022-13027

Steele AD, Lindquist S, and A Aguzzi (2007) The prion protein knockout mouse: a phenotype under challenge. Prion 1(2):83-93.

Bordone L, Cohen D, Robinson A, Motta MC, van Veen E, Czopik A, Steele AD, Crowe H, Marmor S, Luo J, Gu W, and L Guarente (2007) SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 6(6):759-767

Steele AD, Jackson WS, King OD, and S Lindquist (2007) The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington’s and prion diseases. Proc Natl Acad Sci USA 104(6): 1983-1988

Steele AD and CH Yi (2006) Neuromuscular denervation: BAX up against the wall in ALS. The Journal of Neuroscience 26(50): 12849-12851

Steele AD*, Emsley JG*, Ozdinler PH, Lindquist S, and JD Macklis (2006) Prion protein (PrPC) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis. Proc Natl Acad Sci USA 103(9):3416-21

Zhang CC, Steele AD, Lindquist S, and HF Lodish (2006) Prion protein is necessary for self-renewal of long-term repopulating hematopoietic stem cells. Proc Natl Acad Sci USA 103(7):2184-9


* These authors contributed equally to this work/co-corresponding authors